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Crospovidone

Polyvinylpolypyrrolidone (Polyvinyl polypyrrolidone, PVPP, Crospovidone, Crospolividone, or E1202) is a highly cross-linked modification of polyvinylpyrrolidone (PVP). The cross-linked form of PVP is used as a disintegrant in pharmaceutical tablets. It is insoluble in water, though it still absorbs water and swells very rapidly generating a swelling force. This property makes it useful as a disintegrant in tablets. PVPP can be used as a drug, taken as a tablet or suspension to absorb compounds (so-called endotoxins) that cause diarrhea. It is also used as a fining to extract impurities (via agglomeration followed by filtration). PVPP forms bonds similar to peptidic bonds in protein (especially, like proline residues) and that is why it can precipitate tannins the same way as proteins do.

Crospovidone

Other names: Polyvinyl polypyrrolidone, Crospovidone, Crospolividone, E1202, Kollidon CL. CAS Number: 25249-54-1. Abbreviations: PVPP. It has E number code E1202 and is used as a stabiliser.

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